Current status of potential therapeutic candidates for the COVID-19 crisis
Autor
Zhang, Jiancheng
Xie, Bing
Hashimoto, Kenji
Institución
Resumen
As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept through 213
countries and infected more than 1,870,000 individuals, posing an unprecedented threat to international health
and the economy. There is currently no specific treatment available for patients with COVID-19 infection. The
lessons learned from past management of respiratory viral infections have provided insights into treating COVID19. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral
therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. A number of
these therapies have provided substantially curative benefits in treating patients with COVID-19 infection.
Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and
identify potential therapeutic targets to develop new drugs for treating COVID-19. Herein, we summarize the
current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness.