Remdesivir and its antiviral activity against COVID-19: A systematic review
Autor
Frediansyah, Andri
Nainu, Firzan
Dhama, Kuldeep
Mudatsir, Mudatsir
Harapan, Harapan
Institución
Resumen
Background
To summarize the antiviral activities of remdesivir against SARS-CoV-2, the causative agent of COVID-19.
Methods
Available publications were systematically explored on some databases and gray literature was examined. Publications were discussed narratively.
Results
Remdesivir inhibits SARS-CoV-2 replication, reduces viral load, and exerts protective effects in SARS-CoV-2 infected animals. Remdesivir also reduces the pathological process, alleviates mild symptoms, and improves pulmonary lesions in SARS-CoV-2-infecetd animals. Although remdesivir has been used as a compassionate drug for treating COVID-19 patients, it has only moderate efficacy.
Conclusion
Although remdesivir has shown potent antiviral activities, more efficacy assessments are urgently warranted in clinical trials.