Immunopathology, host-virus genome interactions, and effective vaccine de‐ velopment in SARS-CoV-2
Autor
Singh, Desh Deepak
Han, Ihn
Choi, Eun-Ha
Kumar Yadav, Dharmendra
Institución
Resumen
Coronaviruses are a group of enveloped RNA viruses that are diversely found in humans and
now declared a global pandemic by the World Health Organization in March 2020. The
population's susceptibility to these highly pathogenic coronaviruses has contributed to large
outbreaks, evolved into public health events, and rapidly transmitted globally. Thus, there is an
urgent need to develop effective therapies and vaccines against this disease. In the primary
stage of severe acute respiratory syndrome coronavirus (SARS-COV-2) infection, the signs
and symptoms are nonspecific, and many more cases have been observed than initially
expected. Genome sequencing is performed regularly to identify genetic changes to SARSCOV-2, and vaccine development is focused on manufacture, production, and based on specific
problems, and very few are available on recent developments in the prevention of outbreaks.
The aim of this review article to explore recent updates on SARS-COV-2 in the context of
pathogenesis during disease progression, and innate acquired mechanisms of defense, This
includes advances in diagnostics, susceptibility, and severity of host-virus genome interactions,
modes of transmission, active compounds being used in pre-clinical and clinical trials for the
treatment of patients, vaccine developments, and the effectiveness of SARS-COV-2 prevention
and control measures. We have summarized the importance of pathophysiology immune
response, Diagnostics, vaccine development currently approaches explored for SARS-COV-2.