Characterization of neonates born to mothers with SARS-CoV-2 infection: review and meta-analysis
Autor
Neef, Vanessa
Buxmann, Horst
Rabenau, Holger F.
Zacharowski, Kai
Raimann, Florian J.
Institución
Resumen
Objective: Characterization of neonates born to mothers with SARS-CoV-2 infection has
been partially carried out. There has been no systematic review providing a holistic neonatal
presentation including possible vertical transmission.
Study design: A systematic literature search was performed using PubMed, Google Scholar
and Web of Science up to June, 6 2020. Studies on neonates born to mothers with SARS7 CoV-2 infection were included. A binary random effect model was used for prevalence and
95% confidence interval.
Results: 32 studies involving 261 neonates were included in meta-analysis. Most neonates
born to infected mothers did not show any clinical abnormalities (80.4%). Clinical features
were dyspnea in 11 (42.3%) and fever in 9 newborns (19.1%). Of 261 neonates, 120 neonates
were tested for infection, of whom 12 (10.0%) tested positive. Swabs from placenta, cord
blood and vaginal secretion were negative.
Conclusions: Neonates are mostly non affected by the mother`s SARS-CoV-2 infection. The
risk of vertical transmission is low.