Therapy of primary liver cancer
Autor
Feng, Mei
Pan, Yisheng
Kong, Ruirui
Shu, Shaokun
Institución
Resumen
Primary liver cancer (PLC) is a fatal disease that affects millions of lives worldwide.
PLC is the leading cause of cancer-related deaths and the rate of incidence is predicted
to rise in the coming decades. PLC can be categorized into three major histological
subtypes: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC),
and combined HCC-ICC (cHCC-ICC). These subtypes are distinct with respect to
epidemiology, clinicopathological features, genetic alterations, and clinical
managements, which are thoroughly summarized in this review. The state of treatment
strategies for each subtype, including the currently approved drugs and the potential
novel therapies, are also discussed.