bachelorThesis
Comportamiento de la troponina, en pacientes con infarto agudo de miocardio, con y sin enfermedad renal crónica, FSFB, 2016 - 2018
Autor
Buitrago Bolívar, Carolina
Espinosa Trujillo, Jorge Andrés
Institución
Resumen
Objetive: Troponin is the most accurate biomarker available to approach the diagnosis and management of acute myocardial injury in the emergency room (ER), however, the interpretation is doubtful in patients with chronic kidney disease (CKD). We evaluate the behavior of Troponin I levels in patients treated for Acute Myocardial Infarction (AMI) with and without CKD. Methodology: With a historical cohort design, patients treated for AMI in the ER of Fundación Santa Fe de Bogotá (years=2016-2018) were studied. Sociodemographic and clinical characteristics related to patients classified with CKD (Glomerular Filtration Rate, CKD-EPI) were identified; the median concentration of the first and second troponin I in patients with or without CKD was compared, and the relationship between patients with or without CKD and the frequency of positive troponin delta (cutoff points=20%) was determined. Results: A total of 423 patients diagnosed with non-ST elevation acute myocardial infarction were reviewed, of whom 194 were excluded for not meeting the inclusion criteria; the frequency of chronic kidney disease was 71.6%. No differences were identified when comparing the frequency of patients with or without CKD who had troponin delta of ±20%. Regarding the associated comorbidities, arterial hypertension was the most frequent associated with chronic kidney disease (P value <0.05). Conclusion: There were no differences in troponin delta for the diagnosis of non-ST elevation myocardial infarction when comparing patients with or without CKD.