bachelorThesis
Marcadores inflamatorios y factores clínicos asociados en niños y adolescentes con infección por SARS COV-2 y la relación con su severidad en dos instituciones de Bogotá
Autor
Rodríguez Suesca, María Angélica
Institución
Resumen
Backround: To date there are few studies that describe the behavior of inflammatory markers, and its relationship with the severity of the disease, in children with SARS CoV-2 infection so it is intended to carry out a case-control study in the pediatric population of the Hospital Universitario Clínica San Rafael (HUCSR) and the Clínica Infantil Colsubsidio (CIC) in the period between April 2020 and March 2022. Methods: A multicenter case-control study was conducted. A random sampling was made, using the information of patients with severe SARS-COV2 as cases vs patients with mild SARS-COV2 as controls, the values of different serum markers of inflammation were compared in a 1:2 ratio. The analysis was done through a bivariate analysis according to the clinical variables of interest. Results: A total of 171 patients, 51 cases, 120 controls were analyzed in a ratio of approximately 1:2. Critically ill patients were smaller than controls (median 19 months vs. 30 months, cases vs. controls, respectively); when evaluating the markers for critical illness, it was found that the absolute count of leukocytes, neutrophils, platelets, LDH, CRP value and D-dimer upon admission to the institution, and the absolute count of lymphocytes, monocytes and platelet count at 72 hours made a significant difference as markers of critical illness. Discussion: The physiological characteristics of infants, maturity of the immunoassay system, vaccination and exposure to pathogens can explain the differences in response to infection when copared to adults, also reflecting the trends observed in the lab. However, leukocytes, platelets, LDH RCP value and D-dimer can guide critical disease in this population. In the same way, the variation in the count of lymphocytes, monocytes and platelets taken in a control at 72 hours of admission.