article
Toxicidad neurológica asociada a la fenitoína en un paciente metabolizador intermedio para la enzima CYP2C19: Neurological toxicity associated with phenytoin in an intermediate metabolizer patient for CYP2C9 enzyme
Registro en:
ISSN: 1139-6202
Autor
Calderon-Ospina, Carlos-Alberto
Dominguez-Dominguez, Camilo Alberto
Aristizabal Gutierrez, Fabio Ancizar
Institución
Resumen
Phenytoin is one of the most used antiepileptics because of its great utility for different types of crisis and low cost. However, its use is limited because the adverse effects, particularly those that affect the central nervous system. This case shows asuccessful pharmaceutical intervention based on pharmacogenetics, to optimize pharmacotherapy with phenytoin in an intermediate metabolizer patient with clear signs of neurotoxicity for this drug.