Artículo de revista
Effects of Cycloleucine in the Nucleus Accumbens Septi on the Elevated plus Maze Test in Rats
Fecha
2020Registro en:
Neuropsychobiology. 79(3):191-197. (2020)
10.1159/000505069
Autor
Gargiulo, Augusto P. I.
Acuña, Andrés
Gargiulo, Mercedes M. L.
Gargiulo, Ángel J. M.
Gargiulo, Marcos C. J.
Baiardi, Gustavo C.
Mora Gutiérrez, Sergio
Lafuente, José Vicente
Romanowicz, Esteban
Landa, Adriana I.
Guevara, Manuel A.
Gargiulo, Pascual Ángel
Institución
Resumen
Introduction: In recent years, an important number of studies have emphasized the psychopharmacological actions of cycloleucine (1-aminocyclopentanecarboxylic acid) acting on the NR1 subunit (glycine allosteric site) of NMDA (N-methyl-D-aspartic acid) receptor. We studied the effects of its injection in an anxiety test. Methods: The elevated plus maze test was used. Male rats bilaterally cannulated into the nucleus accumbens septi (NAS) were employed. Rats were divided into 5 groups that received either 1 mu L injections of saline or cycloleucine (0.5, 1, 2, or 4 mu g) 15 min before testing. Results: Time spent in the open arm was significantly increased by cycloleucine treatment with all doses (1 and 2 mu g, p < 0.05; 0.5 and 4 mu g, p < 0.01), like number of extreme arrivals (0.5 and 1 mu g, p < 0.05; 2 mu g, p < 0.01; and 4 mu g, p < 0.001). Open arm entries were increased by the highest dose only (4 mu g, p < 0.01). Discussion/Conclusion: Present results show no difference between all doses in the time spent in the open arm, suggesting an indirect, noncompetitive action of the drug. The increase in extreme arrivals and open arm entries suggests a dose influence in these parameters. We conclude that cycloleucine influence on the NMDA receptors within NAS leads to anxiolytic-like effects and behavioral disinhibition, which once more confirms the involvement of NAS in anxiety processing.
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Effects of dizocilpine-induced glutamatergic blockade in the nucleus accumbens septi on the plus maze test
Gargiulo, Augusto P. I.; Gargiulo De Aranda, María P.; Gargiulo, Mercedes Maria Lucrecia; Gargiulo, Ángel José Martín; Acuña, Andres; Baiardi, Gustavo Carlos; Lafuente, José V.; Landa De Gargiulo, Adriana I.; Guevara, Manuel Alejandro; Gargiulo, Pascual Angel (De Gruyter, 2018-06)In previous studies, we have observed that specific N-methyl-d-Aspartic acid (NMDA) antagonists and non-NMDA antagonists injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in the plus maze ... -
Effects of cycloleucine in the nucleus accumbens septi on the elevated plus maze test in rats
Gargiulo, Augusto P.I.; Acuña, Andres; Gargiulo, Mercedes Maria Lucrecia; Gargiulo, Ángel José Martín; Gargiulo, Marcos C. J.; Baiardi, Gustavo Carlos; Mora, Sergio; Lafuente, José Vicente; Romanowicz, Esteban Alejandro; Landa, Adriana; Guevara, Manuel Alejandro; Gargiulo, Pascual Angel (Karger, 2020-01)Abstract Introduction: In recent years, an important number of studies have emphasized the psychopharmacological actions of cycloleucine (1-aminocyclopentanecarboxylic acid) acting on the NR1 subunit (glycine allosteric ... -
Alpha and beta noradrenergic mediation of NMDA glutamatergic effects on lordosis behaviour and plasmatic LH concentrations in the primed female rat
Landa, Adriana Inés; Gargiulo, Ángel José Martín; Gargiulo, Mercedes María Lucrecia; Cabrera Kreiker, Ricardo Jorge; Bregonzio Diaz, Claudia; Lafuente Sánchez, José Vicente; Gargiulo, Pascual Angel (Springer Wien, 2009-12)In previous studies we have found that blockade of NMDA (N-Methyl-d-Aspartic-Acid)-type glutamatergic receptor with intracerebroventricular (ICV) selective drugs induces an inhibition of lordosis in ovariectomized (OVX) ...