Artículo de revista
Refractory epilepsy associated with anti-ribosomal P antibodies successfully treated with topiramate
Fecha
2020Registro en:
Journal of Neuroimmunology 340 (2020) 577144
10.1016/j.jneuroim.2020.577144
Autor
Uribe San Martín, R.
Ciampi, E.
Cruz, J. P.
Vásquez, M.
Cárcamo, C.
Institución
Resumen
We report the case of a 25-year-old woman who developed temporal lobe epilepsy associated with systemic lupus erythematosus (SLE). Serum and cerebrospinal fluid samples showed high titers of anti-ribosomal P (anti-P) antibodies with negative anti-NMDAR antibodies. She was receiving prednisone and azathioprine, with normalization of SLE serum markers, but without changes in titers of anti-P antibodies. No seizure control was achieved using valproic acid, levetiracetam and lamotrigine. However, she had a selective response to topiramate, an AMPAR blocker, maintained during 6 years of follow-up. We discuss the pathophysiology of this autoimmune epilepsy associated with high titer anti-P antibodies