Artículo de revista
Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in chilean adolescents: The Santiago longitudinal study
Fecha
2020Registro en:
Pediatric Obesity Volumen: 16 Número: 7 Dec 2020
10.1111/ijpo.12765
Autor
Buchanan, Victoria L.
Wang, Yujie
Blanco, Estela
Graff, Mariaelisa
Albala Brevis, Cecilia
Burrows Argote, Raquel
Santos, José L.
Ángel, Barbara
Lozoff, Betsy
Voruganti, Venkata Saroja
Guo, Xiuqing
Taylor, Kent D.
Chen, Yii-Der Ida
Yao, Jie
Tan, Jingyi
Downie, Carolina
Highland, Heather M.
Justice, Anne E.
Gahagan, Sheila
North, Kari E.
Institución
Resumen
Background The genetic underpinnings of glycemic traits have been understudied in adolescent and
Hispanic/Latino (H/L) populations in comparison to adults and populations of European ancestry.
Objective To identify genetic factors underlying glycemic traits in an adolescent H/L population.
Methods We conducted a genome-wide association study (GWAS) of fasting glucose (FG) and fasting
insulin (FI) in H/L adolescents from the Santiago Longitudinal Study.
Results We identified one novel variant positioned in the CSMD1 gene on chromosome 8 (rs77465890,
effect allele frequency = 0.10) that was associated with FI (beta = -0.299, SE = 0.054, p = 2.72x10(-8))
and was only slightly attenuated after adjusting for body mass index z-scores (beta = -0.252, SE = 0.047,
p = 1.03x10(-7)). We demonstrated directionally consistent, but not statistically significant results in
African and Hispanic adults of the Population Architecture Using Genomics and Epidemiology
Consortium. We also identified secondary signals for two FG loci after conditioning on known variants,
which demonstrate allelic heterogeneity in well-known glucose loci.
Conclusion Our results exemplify the importance of including populations with diverse ancestral origin
and adolescent participants in GWAS of glycemic traits to uncover novel risk loci and expand our
understanding of disease aetiology.