Artículos de revistas
Clinical, pathological and molecular characteristics of Chilean patients with early-, intermediate- and late-onset colorectal cancer
Fecha
2021Registro en:
Cells 2021, 10, 631.
10.3390/cells10030631
Autor
Álvarez, Karin
Cassana, Alessandra
Fuente, Marjorie de la
Canales, Tamara
Abedrapo Moreira, Mario Antonio
López Köstner, Francisco
Institución
Resumen
Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality
rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still
lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean
patients according to the age of diagnosis: early- ( 50 years; EOCRC), intermediate- (51–69 years;
IOCRC), and late-onset ( 70 years; LOCRC). The study included 426 CRC patients from Clinica
Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between
age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according
to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS)
were estimated by the Kaplan–Meier method. We found significant differences between the age of
onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage,
OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors
with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite
instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with
the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.