Artículo de revista
Equine-like H3 avian influenza viruses in wild birds, Chile
Fecha
2020Registro en:
Emerging Infectious Diseases Vol. 26, No. 12, December 2020
10.3201/eid2612.202063
Autor
Bravo Vásquez, Nicolás
Yao, Jiangwei
Jiménez Bluhm, Pedro
Meliopoulos, Victoria
Freiden, Pamela
Sharp, Bridgett
Estrada, Leonardo
Davis, Amy
Cherry, Sean
Livingston, Brandi
Danner, Angela
Schultz Cherry, Stacey
Hamilton West, Christopher
Institución
Resumen
Since their discovery in the United States in 1963, outbreaks
of infection with equine influenza virus (H3N8)
have been associated with serious respiratory disease
in horses worldwide. Genomic analysis suggests that
equine H3 viruses are of an avian lineage, likely originating
in wild birds. Equine-like internal genes have been
identified in avian influenza viruses isolated from wild
birds in the Southern Cone of South America. However,
an equine-like H3 hemagglutinin has not been identified.
We isolated 6 distinct H3 viruses from wild birds in Chile
that have hemagglutinin, nucleoprotein, nonstructural
protein 1, and polymerase acidic genes with high nucleotide
homology to the 1963 H3N8 equine influenza virus
lineage. Despite the nucleotide similarity, viruses from
Chile were antigenically more closely related to avian
viruses and transmitted effectively in chickens, suggesting
adaptation to the avian host. These studies provide
the initial demonstration that equine-like H3 hemagglutinin
continues to circulate in a wild bird reservoir.