This article demonstrates the scope of a design intervention carried out in Llahualco, Los Lagos Region, Chile, with textile artisans of Mapuche-Williche ancestry. In particular, it seeks to question the concept of development as a function of the intercultural context of the village, analyzing the role of women in the transmission of inherited knowledge and new scenarios for validation of that knowledge. Furthermore, the article demonstrates how the assimilation of new artisanal techniques, along with their appropriations and novel uses, is generating new textile traditions for the multicultural territories of southern Chile. This project offers an approach to the principles of cultural integration applicable to design processes, thus enabling us to explore the challenge of interculturality in territories open to globalization.