Artículo
Acquired hemophagocytic syndrome related to parainfluenza virus infection: case report
Fecha
2015Registro en:
Journal of Medical Case Reports. 2015 Apr 08;9(1):78
10.1186/s13256-015-0552-5
Autor
Beffermann, Nicole
Pilcante, Javier
Sarmiento, Mauricio
Institución
Resumen
Abstract
Introduction
We present the case of a patient with acquired hemophagocytic syndrome secondary to parainfluenza virus infection, a complication that has not, to the best of our knowledge, been previously reported.
Case presentation
A 33-year-old Chilean man with fever secondary to parainfluenza 2 virus infection developed progressive cholestasis, hepatosplenomegaly, cytopenia and an increased ferritin level (>2000IU/L). A bone marrow analysis showed hemophagocytosis. Our patient received HLH-94 chemotherapy, and he achieved complete and sustained remission after a two-year follow-up, without the need for hematopoietic stem cell transplantation.
Conclusion
Hemophagocytic syndrome is a severe disease with high mortality. A high index of suspicion is essential to improve survival. A viral etiology is frequent and although Epstein-Barr virus is the most frequently associated, other viruses like parainfluenza can cause this disease.