The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting

dc.creatorHalaney, David L.
dc.creatorSanyal, Arnav
dc.creatorNafissi, Navid A.
dc.creatorEscobedo, Daniel
dc.creatorGoros, Martin
dc.creatorMichalek, Joel
dc.creatorAcevedo, Pedro J.
dc.creatorPérez, William
dc.date.accessioned2019-11-05T14:26:35Z
dc.date.available2019-11-05T14:26:35Z
dc.date.created2019-11-05T14:26:35Z
dc.date.issued2017
dc.identifierHalaney, D. L., Sanyal, A., Nafissi, N. A., Escobedo, D., Goros, M., Michalek, J., Acevedo, P. J., Pérez, W., Patricia Escobar, G., Feldman, M. D., and Han, H. (January 24, 2017). "The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in Compliance With Trabecular Cutting." ASME. J Biomech Eng. March 2017; 139(3): 031012. https://doi.org/10.1115/1.4035585
dc.identifierhttps://www.scopus.com/search/form.uri?display=basic
dc.identifier10.1115/1.4035585
dc.description.abstractThe role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p<0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.
dc.languageeng
dc.relationJournal of Biomechanical Engineering;Vol., 139, No. 3, Mar., 1 2017, Articulo 031012
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rightsAtribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
dc.rightsDerechos Reservados - Universidad de Ciencias Aplicadas y Ambientales
dc.sourcehttps://asmedigitalcollection.asme.org/biomechanical/article-abstract/139/3/031012/371155/The-Effect-of-Trabeculae-Carneae-on-Left?redirectedFrom=fulltext
dc.titleThe Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting
dc.typeArtículo de revista


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