dc.creator | Reyes, César | |
dc.creator | Rojas-Luna, Rocío | |
dc.creator | Aza-Conde, Jorge | |
dc.creator | Tabares, Luisa | |
dc.creator | Patarroyo, Manuel A. | |
dc.creator | Patarroyo, Manuel Elkin | |
dc.date.accessioned | 2019-10-09T16:12:57Z | |
dc.date.available | 2019-10-09T16:12:57Z | |
dc.date.created | 2019-10-09T16:12:57Z | |
dc.date.issued | 2017 | |
dc.identifier | Reyes, C., Rojas-Luna, R., Aza-Conde, J., Tabares, L., Patarroyo, M. A., & Patarroyo, M. E. (2017). Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine development. Biochemical and Biophysical Research Communications, 489(3), 339-345. doi:10.1016/j.bbrc.2017.05.123 | |
dc.identifier | 0006-291X | |
dc.identifier | https://udca.elogim.com:2119/science/article/pii/S0006291X17310161?via%3Dihub | |
dc.identifier | 10.1016/j.bbrc.2017.05.123 | |
dc.description.abstract | A vaccine candidate component must fit perfectly into the antigen presenting HLA-DRβ* molecule's groove (or canonical nonapeptide) peptide binding region (PBR) during antigen presentation to the T-cell receptor (TCR), conforming a specific and stable macromolecular complex and induce an appropriate immune response.
Antigen's peripheral flanking residues (PFR, positions (p) -p2 and p10) must thus establish strong interactions with the HLA-DRβ* - TCR complex. These amino acids (aa) have specific physico-chemical characteristics enabling differentiation between non-protective but antibody-inducer (NPAI), short-lived protection inducer (SLPI) and long-lasting protection inducer (LLPI) peptides when used as an antimalarial vaccine component. Their identification (through 1H-NMR and Aotus monkey immunization) and proper modification contributes to a logical and rational methodology for long-lasting and protective immunological memory. | |
dc.language | eng | |
dc.relation | Biochemical and Biophysical Research Communications;Vol. 489, No. 3, Jul., 29 2017, páginas 339-345 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.rights | Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0) | |
dc.rights | Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales | |
dc.source | https://udca.elogim.com:2119/science/article/pii/S0006291X17310161?via%3Dihub | |
dc.title | Critical role of HLA-DRb* binding peptides' peripheralflankingresidues in fully-protective malaria vaccine development | |
dc.type | Artículo de revista | |