Artículo
Hyperleptinemia as a prognostic factor for preeclampsia: a cohort study
Autor
Mendieta Zerón, Hugo; 45175
GARCIA SOLORIO, VERONICA JACKELINE; 328553
NAVA DIAZ, PAMELA;#0000-0002-3004-5379
GARDUÑO ALANIS, ADRIANA; 225677
SANTILLAN BENITEZ, JONNATHAN GUADALUPE; 238940
DOMINGUEZ GARCIA, MA. VICTORIA; 85954
ESCOBAR BRIONES, CAROLINA; 12876
DENOVA GUTIERREZ, EDGAR; 49363
Mendieta Zerón, Hugo
GARCIA SOLORIO, VERONICA JACKELINE
NAVA DIAZ, PAMELA
GARDUÑO ALANIS, ADRIANA
SANTILLAN BENITEZ, JONNATHAN GUADALUPE
DOMINGUEZ GARCIA, MA. VICTORIA
ESCOBAR BRIONES, CAROLINA
DENOVA GUTIERREZ, EDGAR
Institución
Resumen
Summary: Introduction: Leptin is an adipokine which has a direct relationship to obesity. Our aim was to measure this hormone in pregnant women at three months intervals throughout their pregnancies to determine the serum value of those who developed preeclampsia. Material and Methods: We followed 19 women (median age 24.8 ± 5.7 years) with pre-gestational Body Mass Index (BMI) less than 25 kg/m2, 21 (median age 26.1 ± 4.6 years) with BMI higher than 25 kg/m2 and 16 (median age 30.9 ± 5.8 years) with Gestational Diabetes Mellitus (GDM) (median age 30.9 ± 5.8 years), recruited in the 1st trimester of pregnancy. Serum levels of leptin were measured with radioimmunoassay (RIA) technique. Results: In the first trimester of pregnancy leptin levels showed statistically significant differences between normal weight and overweight-obese women (p < 0.001), diabetic women (p < 0.05) and the subgroup of preeclamptic women (p < 0.001). For those women with PGBMI ≥ 40 kg/m2 and leptin ≥ 40 ng/ml in the second trimester, the Odds Ratio (OR) to develop preeclampsia was of 47.95% CI (4.1–527.2). Analyzing leptin values with ROC curves, the greatest area under the curve (AUC) was for leptin in the second trimester (0.773, CI: 0.634–0.911). Conclusion: Women with morbid obesity (BMI ≥ 40 kg/m2) had significantly higher levels of serum leptin (p < 0.01) and a value of 40 ng/ml of this hormone seems to be predictive of developing preeclampsia in this group of patients.