Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus

dc.creatorGabrielsen, Mads
dc.creatorRey Burusco, María Florencia
dc.creatorGriffiths, Kate
dc.creatorRoe, Andrew J.
dc.creatorCooper, Alan
dc.creatorSmith, Brian O.
dc.creatorKennedy, Malcolm W.
dc.creatorCórsico, Betina
dc.date2012
dc.date2019-10-25T15:31:42Z
dc.identifierhttp://sedici.unlp.edu.ar/handle/10915/84080
dc.identifierissn:1744-3091
dc.descriptionNa-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.
dc.descriptionInstituto de Investigaciones Bioquímicas de La Plata
dc.formatapplication/pdf
dc.format835-838
dc.languageen
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rightsCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.subjectCiencias Médicas
dc.subjectfatty acid- and retinol-binding proteins
dc.subjectNa-FAR-1
dc.subjectNecator americanus
dc.subjectparasitic nematodes
dc.titleTwo crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
dc.typeArticulo
dc.typeArticulo


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