Artículos de revistas
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
Fecha
2019Registro en:
American Journal of Physical Anthropology, Volumen 168, Issue 3, 2019, Pages 438-447
10968644
00029483
10.1002/ajpa.23756
Autor
Delgado, Miguel
Ramírez, Luis Miguel
Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Zanolli, Clément
González José, Rolando
Canizales, Samuel
Bortolini, Maria Catira
Poletti, Giovanni
Gallo, Carla
Rothhammer Engel, Francisco
Bedoya, Gabriel
Ruiz Linares, Andrés
Institución
Resumen
© 2018 Wiley Periodicals, Inc. Objectives: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods: We characterized a sample from Colombia (N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome-wide SNP data. We tested for correlation between dental traits, genetic ancestry, age, and sex. We carried out a biodistance analysis between the Colombian sample and reference continental population samples using the mean measure of divergence statistic calculated from dental trait frequencies. We evaluated the inference of genetic ancestry from dental traits using a regression approach (with 10-fold cross-validation) as well as by testing the correlation between estimates of ancestry obtained from genetic and dental data. Results: Latin Americans show intermediate dental