Artículos de revistas
HPV-mediated resistance to TNF and TRAIL is characterized by global alterations in apoptosis regulatory factors, dysregulation of death receptors, and induction of ROS/RNS
Fecha
2019Registro en:
International Journal of Molecular Sciences, Volumen 20, Issue 1, 2019,
14220067
16616596
10.3390/ijms20010198
Autor
Cabeça, Tatiane Karen
Abreu, Alice de Mello
Andrette, Rafael
Lino, Vanesca de Souza
Morale, Mirian Galliote
Aguayo, Francisco
Termini, Lara
Villa, Luisa Lina
Lepique, Ana Paula
Boccardo, Enrique
Institución
Resumen
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.Persistent infection with high-risk human papilloma virus (HR-HPV) is the main risk factor for the development of invasive cervical cancer although is not sufficient to cause cervical cancer. Several host and environmental factors play a key role in cancer initiation/progression, including cytokines and other immune-response mediators. Here, we characterized the response to the individual and combined action of the pro-inflammatory cytokines tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand (TRAIL) on HPV-transformed cells and human keratinocytes ectopically expressing E6 and E7 early proteins from different HPV types. We showed that keratinocytes expressing HPV early proteins exhibited global alterations in the expression of proteins involved in apoptosis regulation/execution, including TNF and TRAIL receptors. Besides, we provided evidence that TNF receptor 1 (TNFR1) was down-regulated and may be retained in