Artículos de revistas
Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide
Fecha
2019Registro en:
Gastroenterology, Volumen 156, Issue 5, 2019, Pages 1368-1380.e10
15280012
00165085
10.1053/j.gastro.2018.12.005
Autor
Piano, Salvatore
Singh, Virendra
Caraceni, Paolo
Maiwall, Rakhi
Alessandria, Carlo
Fernandez, Javier
Soares, Elza Cotrim
Kim, Dong Joon
Kim, Sung Eun
Marino, Monica
Vorobioff, Julio
Barea, Rita de Cassia Ribeiro
Merli, Manuela
Elkrief, Laure
Vargas, Victo
Institución
Resumen
© 2019 AGA InstituteBackground & Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Methods: We collected data from 1302 hospitalized patients with cirrhosis and bacterial or fungal infections at 46 centers (15 in Asia, 15 in Europe, 11 in South America, and 5 in North America) from October 2015 through September 2016. We obtained demographic, clinical, microbiology, and treatment data at time of diagnosis of infection and during hospitalization. Patients were followed until death, liver transplantation, or discharge. Results: The global prevalence of multidrug-resistant (MDR) bacteria was 34% (95% confidence interval 31%–37%). The prevalence of MDR bacteria differed significantly among geographic areas, wi