Artículo de revista
The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells
Fecha
2018Registro en:
19336926
19336918
10.1080/19336918.2018.1506652
Autor
Villanueva, Andrea A.
Puvogel, Sofía
Lois, Pablo
Muñoz-Palma, Ernesto
Ramírez Orellana, Manuel
Lubieniecki, Fabiana
Casco Claro, Fernando
Gallegos, Iván
García-Castro, Javier
Sanchez-Gomez, Pilar
Torres, Vicente A.
Palma, Verónica
Institución
Resumen
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells.