Artículos de revistas
Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls
Fecha
2018Registro en:
Clinical Epigenetics, Volumen 10, Issue 1, 2018,
18687083
18687075
10.1186/s13148-018-0553-5
Autor
Binder, Alexandra M.
Stiemsma, Leah T.
Keller, Kristen
Van Otterdijk, Sanne D.
Mericq, Verónica
Pereira, Ana
Santos, José Luis
Shepherd, John
Michels, Karin B.
Institución
Resumen
© 2018 The Author(s). Background: Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ER-α on adolescent breast composition has not been previously studied and could serve as a marker of pubertal health and susceptibility to breast cancer. We investigated the association between ER-α DNA methylation in leukocytes and breast composition in adolescent Chilean girls enrolled in the Growth and Obesity Cohort Study (GOCS) in Santiago, Chile. Breast composition (total breast volume (BV; cm3), fibroglandular volume (FGV; cm3), and percent fibroglandular volume (%FGV)) was measured at breast Tanner stage 4 (B4). ER-α promoter DNA methylation was assessed by pyrosequencing in blood samples collected at breast Tanner stages 2 (B2; n = 256) and B4 (n = 338). Results: After adjusting for fat percentage at breast density measurement, ER-α methylation at B2, and cel