info:eu-repo/semantics/article
Toxic Epidermal Necrolysis Successfully Treated With Infliximab
Fecha
2013-01-01Registro en:
1018-9068
instname: Universidad Icesi
reponame: Biblioteca Digital
Autor
Ramírez Escobar, Andrés Felipe
Serrano Reyes, Carlos Daniel
Institución
Resumen
Toxic epidermal necrolysis (TEN) is a life-threatening
drug-induced cutaneous reaction characterized by widespread
apoptosis and detachment of the epidermis. The main causes
of death are secondary infections resulting from epidermal
damage and multiorgan failure [1]. The severity of illness
score (SCORTEN) [2] analyzes 7 independent risk factors
and predicts mortality. Older age, significant comorbidity, and
greater skin involvement correlate with a worse prognosis [2].
The pathogenesis of TEN is unknown. Several studies
suggest that tumor necrosis factor (TNF) α released from
inflammatory cells and activated keratinocytes in the epidermis
plays an important role in the immune response by inducing
direct cytotoxicity and apoptosis [3].