Artículos de revistas
Estudio de dosis flexibles de paliperidona ER en pacientes con esquizofrenia previamente tratados sin efectividad con otros antipsicóticos
Date
2012-06-01Author
Arango Dávila, César Augusto
Córdoba, Rodrigo
Cano, Juan Fernando
Miranda, Carlos
Holguín, Jorge
Fernández, Darío
Márquez, Miguel
Gargoloff, Pedro
Lucchetti, César
Lupo, Christian
Petracca, Gustavo
Institutions
Abstract
Background
Extended-release (ER) paliperidone is an innovative atypical antipsychotic that allows minimal peak-to-through fluctuations with once-daily dosing.
Objective
To evaluate effectiveness, safety and tolerability of flexible, once-daily doses of paliperidone ER (3–12 mg/day) in patients with schizophrenia from Argentina and Colombia who had previously failed treatment with other antipsychotic agents.
Methods
The authors conducted a 6-month, open-label, prospective and multicentric study. Effectiveness was assessed with Positive and Negative Syndrome Scale (PANSS) and Personal and Social Performance scale (PSP). Other measures of effectiveness, safety and tolerability, were also conducted.