Thesis
PROPUESTA DE MEJORA UTILIZANDO DISEÑO DE EXPERIMENTOS EN EL DESARROLLO DE TÉCNICAS ANALÍTICAS EN UN LABORATORIO FARMACÉUTICO
Autor
C. BARAJAS GONZÁLEZ, NANCY
Institución
Resumen
This work arises from the need for quality control laboratory to optimize the instrumental analysis
techniques in the development of drugs in a pharmaceutical company to reduce the analysis time
of samples proposed by designing experiments a new method of analysis to optimize the process
control and product release in compliance with the standards.
To achieve this, made a series of experiments where we used a team of high resolution
chromatography (HPLC) to determine the concentration of compound isosorbide dinitrate tablets
presentation, changing the length of chromatographic column is currently using and modifying
some factors influencing the chromatographic process to improve analysis times and improved use
this technique in similar products.
We analyzed the different factors influencing the chromatographic process for the modification of
the factors to be used, by design of experiments allowed to determine the combination of factors
that enable us to reduce the retention time of the compound. By reducing the compound
retention time, reducing overall analysis time and consumption of solvents used in
chromatography, making the process more efficient. Improved technique can be implemented in
other similar tests