Thesis
La Radiocirugía como Alternativa de Tratamiento en la Epilepsia del Lóbulo Temporal Recidivante
Autor
GARCIA MUÑOZ, LUIS
Institución
Resumen
Background: The temporal lobe epilepsy has a poor pharmacological response
in 40 % of the patients. The surgery is effective for free or reduction seizure
activity. Unfortunately 20 % of the cases have a relapse in 5 years and the
cause is an incomplete hippocampus resection. Radiosurgery produces
necrosis and is effective in the treatment of the brain tumors, arteriovenous
brain malformations and some functional disorders. Objective: Demonstrate
that radiosurgery is an effective treatment for the temporal lobe epilepsy.
Material and Methods: A clinical control assay with no random maneuver was
made in 7 patients with new seizure activity after temporal lobe epilepsy
surgery. They received radiosurgery (30 Gy) in the remnant hippocampus at the
Hospital General de México, during 2002 – 2008. We evaluate the Engel stage,
the number of seizures before and after the treatment and the side effects in the
memory and language. The effects of the radiosurgery in the hippocampus
were determinate with spectroscopy. The statistical analysis for the results
included Student’s T, Friedman and paired T tests. Results: At two years after
treatment, all the patients had an important reduction of the seizure activity and
they passed from the Engel Stage IV to I-II (p<0.05). No important adverse
effects were reported in memory and language status. The targeted
hippocampus was eliminated by necrosis in all the treated cases (p<0.05).
Conclusions: The radiosurgery is an effective treatment for the epilepsy lobe
surgery after surgical treatment failure.