Article
Regioselective and Versatile Synthesis of Indoles via Intramolecular Friedel–Crafts Heteroannulation of Enaminones
Autor
Cruz lopez, María del Carmen
Institución
Resumen
A new approach is described for the synthesis of substituted
indoles 5, through an intramolecular and regioselective
Friedel–Crafts cyclization of enaminones 6a–h catalyzed by Lewis
acids. Compounds 6 were prepared from the 2-anilinocarbonyl
compounds 7, by treatment with DMFDMA under thermal or microwave
(MW) irradiation conditions. An alternative and shorter
one-pot two-step synthesis of indoles 5 was achieved starting from
compounds 7 and promoted by MW radiation, including the elusive
2-acetylindoles 5i–m.