Tesis
Estudo sobre a expressão da metaloproteinase de matriz 7 (MMP-7), a infecção pelos Vírus HPV e EBV e o grau de malignidade de lesões do colo uterino
Fecha
2016-04-20Registro en:
Autor
Silva, Naiara Soares Melo da
Institución
Resumen
Cervical cancer is the second largest cause of deaths from malignant cancer
among women worldwide. Many studies show the importance of the HPV virus
in the onset of cervical cancer, but because of the monoclonal nature of this
cancer, it is suspected that HPV infection may not be considered the only
causal factor responsible for the development of cervical carcinoma. Studies
have indicated that EBV may have a role in cooperation with the HPV16 tumor
development. Such cooperation could influence the tumor microenvironment by
creating a favorable niche for its progression. Cancer cells secrete enzymes
that degrade the extracellular matrix (ECM). Such enzymes such as matrix
metalloproteinases (MMPs) facilitate cell movement in tissues and induce the
activity of growth factors that promote angiogenesis. Among the group of
MMPs, MMP-7 seems to have a crucial role in the development of
carcinogenesis, since its action has been associated with the cleavage and
release of adhesion molecules important. In this sense, this study was
performed to establish the relationship between the HPV coinfection / EBV and
expression of MMP-7. They were examined immunohistochemically histological
slides of cervical lesions biopsies of 60 patients aged 35 to 65 years. The
samples were divided into high grade lesion and low grade and evaluated
semiquantitatively by scoring system ranging from 0 to +++. Histopathological
indexes the degree of injury were established. It observed a statistically
significant association between high-grade lesion, the expression of MMP-7 and
the presence of the HPV virus, with p = 0.007 at the junction portion
squamocolumnar and p = 0.023 in the portion of the ectocervix.