Síntese de complexos semi-sanduíche n6-p-cimeno- Ru(II) contendo ligantes binitrogenados, interação com o DNA e potenciais atividades farmacológicas / Legna Andreina Colina Vegas

Abstract

The synthesis, spectroscopic characterization, crystal structures and electrochemistry of π-arene piano-stool ruthenium (II) complexes with pyridine or derivatives as nitrogen donor ligands are described. A series of six organometallic compounds of formulae [RuCl(η6-p-cymene)(N∩N)]PF6 [N∩N=1,10’-phenantroline (phen), 4,7’-diphenil-1,10’-phenantroline (phphen), 2,2’-bipyridine (bipy), 5,5’-dimethyl-2,2’-bipyridine (mebipy), 4,4’-dimethoxi-2,2’-bipyridine (meobipy) and 4,4’-di-t-buthyl-2,2’-bipyridine (butbipy)]were synthesized and fully characterized. The solid state structures of the six complexes were determined by X-ray crystallography and their characterization was completed by FT-IR spectroscopy, molar conductivity and NMR studies (1H and 13C). Electrochemical experiments were performed by cyclic voltammetry to estimate the redox potential of the Ru(II)/Ru(III) couple and this potential does not vary significantly between the complexes. Additionally, spectroscopic titration with DNAct were done, to estimate interaction constants between the metal complex and this macromolecule. The values of the constants indicate a reversible interaction with DNA, which is in concordance with the literature.