Dissertação
Isolamento do principal constituinte ativo do óleo essencial de Lippia alba (Mill.) N. E. Brown com potencial anestésico geral e estudo do mecanismo de ação
Fecha
2011-01-24Registro en:
HELDWEIN, Clarissa Giesel. ISOLATION OF THE MAIN ACTIVE COMPOUND OF THE ESSENTIAL
OIL OF Lippia alba (MILL.) N. E. BROWN WITH POTENTIAL
ANESTHETIC ACTIVITY AND ITS MECHANISM STUDY. 2011. 110 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2011.
Autor
Heldwein, Clarissa Giesel
Institución
Resumen
Lippia alba (Mill.) N. E. Brown is an aromatic herb commonly used as sedative and
for the treatment of gastrointestinal disturbs. Many literature data confirm the
sedative property of the essential oil (EO) of this species; however, just recently its
anesthetic activity was confirmed. The present study reports the isolation of two
major chemical constituents of the EO of L. alba, linalool and eucalyptol, and also the
evaluation of their anesthetic activity in juveniles of silver catfish (Rhamdia quelen).
Additionally, linalool was defined as the major active compound of the EO with
anesthetic property, and eucalyptol did not presented activity in the tested
concentration. The involvement of GABAergic system on the mechanism of action of
the EO and its major constituent was also studied. The results showed that the EO
contains one or more compounds which act in synergism with linalool and also by
different mechanism. Benzodiazepine like effect was detected for the EO of L. alba,
but not for linalool. In addition, this work brings a case report of contact dermatitis
caused by the leaves of L. alba chemotype linalool. Finally, to establish a good
quality of the plant material, after yield and chemical composition analyses of the EO,
1,0 x 0,8 m was defined as the better spacing for cultivation of L. alba. The results
are presented in three manuscripts.