Dissertação
Avaliação de marcadores inflamatórios e antígenos ABO em pacientes com diagnóstico de câncer de próstata
Fecha
2008-06-20Registro en:
MASTELLA, Aline Klein. EVALUATION OF INFLAMMATORY MARKERS AND ABO ANTIGENS IN PATIENTS DIAGNOSED WITH PROSTATE CANCER. 2008. 81 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2008.
Autor
Mastella, Aline Klein
Institución
Resumen
Prostate cancer (PC) is a disease in men and became the first cause of death by
cancer in Brazil. The carcinogenesis is related to the presence of local inflammatory
process and to the loss of blood group in neoplasic cells. The aim of the study was to
assess the involvement of inflammatory process and the expression of A and B
antigens in prostate cancer. Serological measure of prostatic specific antigen (PSA),
reactive C protein (CRP) and ischemia modified albumin (IMA) was made in healthy,
hyperplasic (BPH) and neoplasic prostate volunteers. PSA values increased when
comparing healthy (1,13 ng/ml), BPH (18,69 ng/ml) and PC (134,68 ng/ml) patients.
IMA showed to be over 0,400 ABSU just in BPH patients. Medium CRP
concentrations did not exceed normal values (5 mg/l) in the studied groups. There
was not a meaningful difference in the evaluation of PSA, CRP and IMA in relation to
the ABO blood group of the patients. The carcinogenesis of prostate seemed to
abolish the expression of A and B antigens in neoplasic cells. Inflammatory feature
showed to be mild in the prostatic alterations and did not reach reference values. IMA
acted as a marker of oxidative stress and patients with BPH demonstrated
concentration above 0,400 ABSU. The diagnosis of BPH must be considered when
IMA is being used as a marker of myocardial ischemia. The ABO blood group of the
volunteers did not show difference in the analysis of PSA, CRP and IMA.