| dc.description.abstract | As a part of our ongoing search of new bioactive secondary metabolites of plant origin,
the aerial parts of Lupinus lanatus were subjected to phytochemical investigation.
Lupinus genus, belonging to the family of Leguminosae (Fabaceae), is widely distributed
in south and western North America, in the Mediterranean region and Africa, with
approximately 600 species. In Rio Grande do Sul, Brazil, the genus is represented by 13
species, among them, L. lanatus. This is a small shrub native to South America, mainly
south Brazil (Rio Grande do Sul), Uruguai, Paraguai and Argentine. In Rio Grande do
Sul, L. lanatus is called tremoço, and it is used in folk medicine as an antidiabetic,
antifungal, antitumor and antioxidant agent. Quinolizidine alkaloids, such as lupanine,
multiflorine, sparteine and argirine, are widely distributed in plants of the genus. Their
biological effects, as antiarrhythmic, hypoglycemic, hypotensive, depressing CNS,
hallucinogenic and respiratory stimulant activities, among others, has been studied
previously. In the present paper, we describe the isolation and structural elucidation of a
new quinolizidine alkaloid, lanatine A together with 13-α-cinnamoyloxylupanine, and
hydroxylupanine from the leaves, and (-)multiflorine and (-)13-α-cis-tigloyloxymultiflorine
from the seeds of L. lanatus. | |
