dc.contributorMombach, Jose Carlos Merino
dc.contributorhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784663P5
dc.contributorPassetti, Fabio
dc.contributorhttp://lattes.cnpq.br/4216542239143600
dc.contributorZimmer, Fábio Mallmann
dc.contributorhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4775428P9
dc.contributorCalegari, Eleonir João
dc.contributorhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4765559T0
dc.contributorVizzotto, Juliana Kaizer
dc.contributorhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4707957A6
dc.creatorSimão, Eder Maiquel
dc.date.accessioned2017-05-05
dc.date.accessioned2019-05-24T19:34:08Z
dc.date.available2017-05-05
dc.date.available2019-05-24T19:34:08Z
dc.date.created2017-05-05
dc.date.issued2012-07-09
dc.identifierSIMÃO, Eder Maiquel. Dynamics of pre-cancer to cancer transition: a study of expression pathways of genome maitenance. 2012. 101 f. Tese (Doutorado em Física) - Universidade Federal de Santa Maria, Santa Maria, 2012.
dc.identifierhttp://repositorio.ufsm.br/handle/1/3903
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/2835125
dc.description.abstractThe loss of genomic stability associated with genetic deterioration is one of the many important aspects for the development of carcinomas. The genome maintenance mechanisms (GMM) ensure the integrity of DNA and cell survival. They are composed of genetic pathways that include the cell cycle checkpoints, DNA repair and recombination, programmed cell death (apoptosis) and senescence. The purpose of the work is to investigate the activity of these pathways in genome maintenance in diseases related to the evolution of cancer. For this public data from microarrays obtained from the Gene Expression Omnibus (GEO) database were used. We analized the expression of proteins and genome maintenance pathways that are altered in pre-cancerous and cancerous tissues related to genomic instability and may lead to tumor progression. The results allowed a quantitative characterization of an anti-cancer barrier in the tumor evolution proposed in the literature.
dc.publisherUniversidade Federal de Santa Maria
dc.publisherBR
dc.publisherFísica
dc.publisherUFSM
dc.publisherPrograma de Pós-Graduação em Física
dc.rightsAcesso Aberto
dc.subjectVias de manutenção do genoma
dc.subjectCâncer
dc.subjectMicroarranjos
dc.subjectPathways in genome maintenance
dc.subjectCancer
dc.subjectMicroarrays
dc.titleDinâmica da transição pré-câncer para câncer: estudo da expressão de vias de manutenção do genoma
dc.typeTese


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