Artículos de revistas
Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
Fecha
2014-09-01Registro en:
Clinics. Faculdade de Medicina / USP, v. 69, n. 9, p. 621-626, 2014.
1807-5932
1980-5322
S1807-59322014000900621.pdf
S1807-59322014000900621
10.6061/clinics/2014(09)08
WOS:000343983100008
Autor
Vieira, Michele Juliane
Perosa, Sandra Regina
Argañaraz, Gustavo Adolfo
Silva Junior, Jose Antonio
Cavalheiro, Esper Abrão
Naffah-Mazzacoratti, Maria da Graca
Institución
Resumen
OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules.METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry.RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin.CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.