Artigo
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus
Fecha
2012-04-01Registro en:
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 2, p. 374-380, 2012.
0102-695X
S0102-695X2012000200018.pdf
S0102-695X2012000200018
10.1590/S0102-695X2011005000219
WOS:000299742200018
Autor
Cabral, Rodrigo Sant'Ana
Sartori, Maura Casari
Cordeiro, Inês
Queiroga, Carmen Lucia
Eberlin, Marcos Nogueira
Lago, Joao Henrique Ghilardi [UNIFESP]
Moreno, Paulo Roberto Hrihorowitsch
Young, Maria Claudia Marx
Institución
Resumen
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).