Artículos de revistas
Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 6, p. 699-709, 2001.
Nader, Helena Bonciani
Pinhal, Maria Aparecida da Silva
Baú, Elaine Cristina
Castro, Ricardo Augusto Braga de
Medeiros, Guilherme Fulgencio
Chavante, Suely Ferreira
Leite, Edda Lisboa
Trindade, Edvaldo da Silva
Shinjo, Samuel Katsuyuki
Rocha, Hugo Alexandre Oliveira
Tersariol, Ivarne Luis dos Santos
Dietrich, Carl Peter
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.
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Antithrombotic and Antioxidant Activity of Amaranth Hydrolysate Obtained by Activation of an Endogenous Protease Sabbione, Ana Clara; Ibañez, Sabrina M.; Martinez, Estela Nora; Añon, Maria Cristina; Scilingo, Adriana Alicia (Springer, 2016-06)Ingestion of diets with antithrombotic and antioxidant components offer a convenient and effective way to prevent and reduce the incidence of cardiovascular diseases. The aim of the present work was to obtain an amaranth ...
Early blood pressure lowering in patients with intracerebral haemorrhage and prior use of antithrombotic agents: pooled analysis of the INTERACT studies Lili, Song; Sandset, Else Charlotte; Arima, Hisatomi; Heeley, Emma; Delcourt, Candice; Chen, Guofeng; Yang, Jie; Wu, Guojun; Wang, Xia; Lavados Germain, Pablo Manuel; Huang, Yining; Stapf, Christian; Wang, Jiguang; Robinson, Thompson; Chalmers, John; Lindley, Richard I.; Anderson, Craig S. (BMJ Publishing Group, 2016-12)Objective Antithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse outcomes. We determined differential effects of early blood pressure (BP) lowering in patients with/without ...
Aspirin versus aspirin plus clopidogrel as antithrombotic treatment following transcatheter aortic valve replacement with a balloon-expandable valve the ARTE (aspirin versus aspirin plus clopidogrel following transcatheter aortic valve implantation) randomized clinical trial Rodes Cabau, Josep; Masson, Jean Bernard; Welsh, Robert C.; García del Blanco, Bruno; Pelletier, Marc; Webb, John G.; Al Qoofi, Faisal; Genereux, Philippe; Maluenda Razeto, Gabriel; Thoenes, Martin (Elsevier, 2017)OBJECTIVES The aim of this study was to compare aspirin plus clopidogrel with aspirin alone as antithrombotic treatment following transcatheter aortic valve replacement (TAVR) for the prevention of ischemic events, bleeding ...