Abstract. The great contemporary organizational challenge for enterprises is to create a conceptual and methodological framework allows the management of knowledge by means of networks designed for social interaction. This statement is based on the premise that the competitive drive and sustainable success of the company depend on the introduction of new forms of production innovative processes, which can only be ensured through integrated approaches to knowledge management and the incorporation information technologies (IT). This is a reality that has already been accepted by the Brazilian Agricultural Research Corporation (Embrapa, its acronym in Portuguese), a Brazilian research, development, and innovation (RD&I) institution supporting agricultural sector. For some years now, Embrapa has been incorporating what it has learned about knowledge management into its strategic planning process. In this paper, we present a new approach to managing knowledge and information, and we analyze the need for research institutions to administer the knowledge they produce through an RD&I management model based multi- and inter-disciplinary teams, and multi-institutional research networks.2011