Artículos de revistas
Inhibitory effect of biofilm-forming Lactobacillus kunkeei strains against virulent Pseudomonas aeruginosa in vitro and in honeycomb moth (Galleria mellonella) infection model
Fecha
2017-11-10Registro en:
Berríos P; Fuentes JA; Salas D; Carreño A; Aldea P; Fernández F; Trombert AN. Inhibitory effect of biofilm-forming Lactobacillus kunkeei strains against virulent Pseudomonas aeruginosa in vitro and in honeycomb moth (Galleria mellonella) infection model. Benef Microbes. 2018 Feb 27;9(2):257-268
1876-2883
ESSN: 1876-2891
WOS:000426461600009
ID de PubMed: 29124967
10.3920/BM2017.0048
Autor
Berrios, P. [Chile. Universidad Mayor. Facultad de Ciencias. Escuela de Biotecnología]
Fuentes, J. A. [Chile. Universidad Andrés Bello. Facultad de Ciencias Biológicas. Laboratorio de Genética y Patogénesis Bacteriana]
Salas, D. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Genómica y Bioinformática]
Carreño, A. [Chile. Universidad Andres Bello. Centro de Nanociencias Aplicadas - CANS]
Aldea, P. [Chile. Universidad Mayor. CEAPI Mayor]
Fernández, F. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Genómica y Bioinformática]
Trombert, A. N. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Genómica y Bioinformática]
Institución
Resumen
Biofilms correspond to complex communities of microorganisms embedded in an extracellular polymeric matrix. Biofilm lifestyle predominates in Pseudomonas aeruginosa, an opportunistic Gram negative pathogen responsible for a wide spectrum of infections in humans, plants and animals. In this context, anti-biofilm can be considered a key strategy to control P. aeruginosa infections, thereby more research in the field is required. On the other hand, Lactobacillus species have been described as beneficial due to their anti-biofilm properties and their consequent effect against a wide spectrum of pathogens. In fact, biofilm-forming Lactobacilli seem to be more efficient than their planktonic counterpart to antagonise pathogenic bacteria. In this work, we demonstrated that Lactobacillus kunkeei, a novel Lactobacillus species isolated from honeybee guts, can form biofilms in vitro. In addition, the L. kunkeei biofilm can, in turn, inhibit the formation of P. aeruginosa biofilms. Finally, we found that L. kunkeei strains attenuate infection of P. aeruginosa in the Galleria mellonella model, presumably by affecting P. aeruginosa biofilm formation and/or their stability. Since L. kunkeei presents characteristics of a probiotic, this work provides evidence arguing that the use of this Lactobacillus species in both animals (including insects) and humans could contribute to impair P. aeruginosa biofilm formation.
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