Artículos de revistas
Leaves of eugenia brasiliensis used as a folk medicine contain cyclooxygenase enzyme and lipid peroxidation inhibitory compounds
Fecha
2018-01-01Registro en:
Natural Product Communications, v. 13, n. 8, p. 977-980, 2018.
1555-9475
1934-578X
2-s2.0-85052103052
4702004904231248
0000-0002-1516-7765
Autor
Universidade Estadual Paulista (Unesp)
Michigan State University
Chongqing University
Institución
Resumen
Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8’R-7,8,7’,8’-tetrahydro-8,8’-dimethyl-3,3’-dimethoxy-4,4’-dihydroxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 µg/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 µg/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5µg/mL.