Artículos de revistas
Zn-based porous coordination solid as diclofenac sodium carrier
Fecha
2018-04-01Registro en:
Journal of Solid State Chemistry, v. 260, p. 67-72.
1095-726X
0022-4596
10.1016/j.jssc.2018.01.011
2-s2.0-85042287613
8534138813417161
0000-0003-1574-681X
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Drug delivery systems produced with biocompatible components can be used to reduce adverse effects and improve therapy efficacy. Most of the carrier materials reported in the literature show poor drug loading and rapid release. However, porous hybrid solids, such as metal-organic frameworks, are well suited to serve as carriers for delivery and imaging applications. In this work, a luminescent and nontoxic porous Zn(II) coordination polymer with 4,4′-biphenyl-dicarboxylic acid (BPDC) and adenine linkers (BioMOF-Zn) was synthesized by a solvothermal process and characterized by PXRD, TGA, SEM-FEG, and FTIR. Nitrogen adsorption measurements revealed the presence of micropores as well as mesopores in the framework after activation of the material. The blue-emitting BioMOF-Zn exhibited an outstanding loading capacity (1.72 g g−1) and satisfactory release capability (56% after two days) for diclofenac sodium.