Artículos de revistas
Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvement
Date
2017-11-01Registration in:
Toxicon, v. 138, p. 78-81.
1879-3150
0041-0101
10.1016/j.toxicon.2017.08.019
2-s2.0-85027840671
2-s2.0-85027840671.pdf
Author
Universidade Federal de Pernambuco (UFPE)
Federal University of Ceará
State University of Ceará
Universidade Estadual Paulista (Unesp)
Institutions
Abstract
Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular effects of B. caissarum crude extract (BcE) on isolated perfused kidney and arteriolar mesenteric bed, as well the involvement of prostaglandins and endothelin. BcE did not show any effect on arteriolar mesenteric bed, but increased perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and decreased the percentage of sodium tubular transport on isolated perfused kidney. Indomethacin blocked the renal effects induced by BcE and tezosentan only partially blocked these effects. These results demonstrate the effects of BcE on kidney in situ, suggesting the involvement of prostaglandins and endothelin.