Capítulos de libros
Evolution, structural features, and biochemical diversity of snake venom serine proteinases
Snake Venoms and Envenomation: Modern Trends and Future Prospects, p. 169-213.
Universidade Estadual Paulista (Unesp)
Universidade Estadual do Norte Fluminense Darcy Ribeiro
Snake venom serine proteinases share high sequence homology and are structurally similar to mammalian serine proteinases. Detailed structural comparisons based on highresolution crystal structures highlight structural determinants and indicate the roles of the differences in amino acid sequences, positions and degree of glycosylation and surface charges in modulating and determining their specificity. This makes them especially interesting for a wide range of clinical and diagnostic applications.