Otros
Biopharmaceuticals from microorganisms: from production to purification
Fecha
2016-12-01Registro en:
Brazilian Journal of Microbiology, v. 47, p. 51-63.
1678-4405
1517-8382
10.1016/j.bjm.2016.10.007
S1517-83822016000500051
2-s2.0-85003794105
S1517-83822016000500051.pdf
Autor
Universidade de Sorocaba (UNISO)
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
Universidade de Brasília (UnB)
Institución
Resumen
The use of biopharmaceuticals dates from the 19th century and within 5–10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals.