Artículos de revistas
Metabolic profiles of planktonic and biofilm cells of Candida orthopsilosis
Fecha
2016-10-01Registro en:
Future Microbiology, v. 11, n. 10, p. 1299-1313, 2016.
1746-0921
1746-0913
10.2217/fmb-2016-0025
2-s2.0-85003749666
2901888624506535
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Institución
Resumen
Aim: This study aims to understand which Candida orthopsilosis protein aids fungus adaptation upon its switching from planktonic growth to biofilm. Materials & methods: Ion mobility separation within mass spectrometry analysis combination were used. Results: Proteins mapped for different biosynthetic pathways showed that selective ribosome autophagy might occur in biofilms. Glucose, used as a carbon source in the glycolytic flux, changed to glycogen and trehalose. Conclusion: Candida orthopsilosis expresses proteins that combine a variety of mechanisms to provide yeasts with the means to adjust the catalytic properties of enzymes. Adjustment of the enzymes helps modulate the biosynthesis/degradation rates of the available nutrients, in order to control and coordinate the metabolic pathways that enable cells to express an adequate response to nutrient availability.