Artículos de revistas
Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores
Fecha
2015-09-01Registro en:
Journal of the Brazilian Chemical Society, v. 26, n. 9, p. 1760-1768, 2015.
1678-4790
0103-5053
10.5935/0103-5053.20150151
S0103-50532015000901760
2-s2.0-84941564408
S0103-50532015000901760.pdf
Autor
Universidade Estadual Paulista (Unesp)
Universidade Federal do ABC (UFABC)
Institución
Resumen
Mebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A.