Artículos de revistas
Birth weight, biological maturation and obesity in adolescents: A mediation analysis
Fecha
2017-08-01Registro en:
Journal of Developmental Origins of Health and Disease, v. 8, n. 4, p. 502-507, 2017.
2040-1752
2040-1744
10.1017/S2040174417000241
2-s2.0-85017646874
2-s2.0-85017646874.pdf
9913976858153343
0000-0003-1576-8090
Autor
Universidade Estadual de Londrina (UEL)
Bradford NHS Foundation Trust
Universidade Estadual Paulista (Unesp)
University of Coimbra
Universidade de Lisboa
Institución
Resumen
This study was aimed to investigate associations between birth weight and multiple adiposity indicators in youth, and to examine potential mediating effects by biological maturation. This was a school-based study involving 981 Brazilian adolescents aged between 10 and 17 years. Birth weight was reported retrospectively by mothers. Maturation was estimated by age of peak height velocity. Adiposity indicators included body mass index (BMI), waist circumference and percent body fat estimated from triceps and subscapular skinfolds. Multilevel mediation analyses were performed using the Sobel test, adjusted for chronological age, gestational age, cardiorespiratory fitness and socio-economic status. Except for body fat in girls, biological maturation partly or fully mediated (P<0.05) positive relationships between birth weight with all other obesity indicators in both sexes with their respective values of indirect effects with 95% confidence intervals: BMI [boys: 0.44 (0.06-0.82); girls: 0.38 (0.13-0.64)], waist circumference [boys: 1.14 (0.22-2.05); girls: 0.87 (0.26-1.48)] and body fat [boys: 0.60 (0.13-1.07)]. To conclude, birth weight is associated with elevated obesity risk in adolescence and biological maturation seems to at least partly mediate this relationship.