Artículos de revistas
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives
Fecha
2018-03-01Registro en:
Journal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 29, n. 3, p. 639-648, 2018.
0103-5053
10.21577/0103-5053.20170178
S0103-50532018000300639
WOS:000423214300023
S0103-50532018000300639.pdf
Autor
Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Federal do Espírito Santo (UFES)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by H-1 and C-13 NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 mu g mL(-1) and M. tuberculosis, with MIC90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 mu g mL(-1).