Does the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?

dc.contributorUniversidade Federal de Goiás (UFG)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-27T11:13:21Z
dc.date.available2018-11-27T11:13:21Z
dc.date.created2018-11-27T11:13:21Z
dc.date.issued2016-02-01
dc.identifierAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier Science Bv, v. 195, p. 29-33, 2016.
dc.identifier1566-0702
dc.identifierhttp://hdl.handle.net/11449/165114
dc.identifier10.1016/j.autneu.2016.02.008
dc.identifierWOS:000372762800006
dc.identifierWOS000372762800006.pdf
dc.description.abstractThe present study sought to determine the involvement of median preoptic nucleus (MnPO) in the regulation of the cardiovascular function and renal sympathetic activity in normotensive (NT) and spontaneously hypertensive rats (SHR). MnPO inhibition evoked by Muscimol (4 mM) nanoinjections, elicited fall in MAP and renal sympathoinhibition in NT-rats. Surprisingly, in SHRs these responses were greater than in NT-rats. These results demonstrated, for the first time that MnPO was involved in the tonic control of sympathetic activity in NT and SHRs. Furthermore, our data suggest the MnPO involvement in the increased sympathetic outflow and consequent arterial hypertension observed in SHRs. (C) 2016 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationAutonomic Neuroscience-basic & Clinical
dc.relation0,902
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectArterial pressure
dc.subjectHypertension
dc.subjectMnPO
dc.subjectRenal sympathetic nerve activity
dc.subjectSHR
dc.titleDoes the median preoptic nucleus contribute to sympathetic hyperactivity in spontaneously hypertensive rats?
dc.typeArtículos de revistas


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